ABOUT ME
Adequate experience in “Organochalcogen Chemistry” has enabled me as synthetic Organochalcogen Chemist. The research interest is to involve in the development of novel heterocycles having secondary interactions to the chalcogen atom with specific emphasis on their synthesis and antioxidant activity. In this regards, several efficient antioxidants that showed very good radical-trapping and hydroperoxide-decomposing activities have been synthesized having OH group at the ortho position of chalcogen atom as derivatives of vitamin B6 and vitamin E. Computational chemistry has been used to explain the better understanding of synthetic, mechanistic and biological chemistry. Further, these antioxidants have been evaluated to reduce the production of reactive oxygen species in stimulated human mononuclear cells with minimal toxicity.
EDUCATION
RESEARCH INTERESTS
Novel Organochalcogen Antioxidants
Development of novel organochalcogen compounds as hydroperoxide-decomposing and lipid peroxyl radical-trapping antioxidants.
July 2011 - May 2017 Postdoctoral Researcher
Department of Chemistry - BMC, Uppsala University, Uppsala, Sweden
Postdoctoral Supervisor: Prof. Lars Engman
Mitochondria-Targeting Organoselenium Antioxidant Fluorescent Probes
Design and development of mitochondria-targeting antioxidant probes for the detection of reactive oxygen species (ROS).
Antioxidants for the Protection of Mitochondrial DNA against "Oxidative Stress"
Design and development of multifunctional regenerable antioxidants for the protection of mitochondrial DNA against oxidative stress caused by overproduction of ROS.
Analysis of weak secondary interactions
Study the nature of weak nonbonded intramolecular secondary between a divalent Se and a polar groups (Se...O/N) to stabilize the structure and play an important role in biological antioxidative properties and evaluations.
2006 - 2011 PhD in Organometallic Chemistry
Department of Chemistry, Indian Institute of Technology, Bombay, India
PhD Supervisor: Prof. Harkesh B. Singh
